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This additional metabolic pathway likely accounts for the incremental weight loss difference between the two compounds
Take home message Wegovy (semaglutide) produces significantly more weight loss than liraglutide (Saxenda/Nevolat)
Therefore, switching to semaglutide therapy may decrease oxidative stress more effectively by improving glucose variability compared to continuous dulaglutide therapy
To add to that concern, when people stop taking these medications, they likely will experience weight rebound, often termed Ozempic rebound, where they gain back the fat they lost but not the lost muscle
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