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The Journal of Clinical Pharmacology, 2018
An association has been established between oxidative stress and inflammation, which inevitably plays a crucial role in the pathogenesis of cardiovascular diseases such as atherosclerosis, stroke and HF (41)
Treatment with GLP-1RAs reduces expression of -smooth muscle actin (-SMA) and collagen type I in HSCs, thereby attenuating fibrogenesis ( /Smad and peroxisome proliferator-activated receptor gamma (PPAR), which regulate HSC activation and extracellular matrix (ECM) synthesis ( In vivo studies conducted on animal models of MASLD/MASH have reveal that GLP-1RAs can reduce liver fibrosis scores and collagen deposition, accompanied by decreased inflammatory infiltration and oxidative stress ( Beyond anti-fibrotic effects, GLP-1RAs promote hepatocyte regeneration and repair
Skowyra, M
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