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La activacin de GLP-1R localizados en neuronas del ncleo arcuato estimula la produccin de pro-opiomelanocortina (POMC), que induce la inhibicin de las neuronas productoras de neuropptidoY (NPY), generando una respuesta inhibidora de la ingesta2
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The human GLP-1R has an unusually high activation barrier and is essentially silent in the absence of an agonist ligand, relative to other class B GPCRs (e.g
10.1016/j.celrep.2017.03.005 115
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