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Zepbounds higher effectiveness is attributed to its dual mechanism of action, targeting both GLP-1 and GIP receptors, which enhances appetite suppression and metabolic regulation more than Semaglutide GLP-1 , which works on GLP-1 alone

Specifically, GLP-1RAs appear to exert a direct protective effect on the liver by enhancing hepatic insulin sensitivity by activating the PI3K/Akt signaling pathway, which promotes glucose uptake while reducing gluconeogenesis [46]

[24] [25] Both hormones are rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), resulting in half-lives of approximately 5-7 minutes for GIP and 1-2 minutes for native GLP-1

GLP-1 medications aid weight loss by mimicking a natural hormone that plays a key role in regulating hunger and fullness