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Moreover, CNS GIPR KO and mGIPR-Ab/GLP-1 treatment of wild-type mice both result in reduced activity in pathways associated with immune function, particularly neutrophil degranulation, suggesting that decreased CNS GIPR signalling might reduce obesity-associated inflammation 47,48,49
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Subcutaneous semaglutide is also available at 2.4mg/weekly (brand name Wegovy) for chronic weight management in nondiabetics
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