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Perhaps the closest he comes to this consideration might be his mention of nostril dilation in fearful horses, but he argues that this is the result of an association between fear and the exertions of rapid flight (Darwin, Reference Darwin1872: 130), rather than functioning to detect a source of danger

10.1016/j.cmet.2011.03.010 202 MurphyP

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The effect of polyphenols on gut microbial metabolites in PD models It has been demonstrated that polyphenols modulate the gut microbiota and restore beneficial metabolite profiles, potentially offering neuroprotective effects through the gut-brain axis