A key feature of AD and PD is the deterioration of synaptic transmission in the cortex and limbic structures of the brain in AD and the loss of dopaminergic synapses in the nigrostriatal dopaminergic projection in PD
Additionally, GLP-1 medications may slow down the rate at which the stomach empties after eating, increasing feelings of fullness and satisfaction
References include the SURMOUNT-1 trial publication (Jastreboff et al., New England Journal of Medicine, 2022), the Mounjaro and Zepbound prescribing information (Eli Lilly, 2024), Liu et al., JAMA Internal Medicine, 2018 (steroid-induced hyperglycemia), and American Diabetes Association Standards of Care, 2024
Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults: The Atherosclerosis Risk in Communities study